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2024, 12, v.43 1326-1333
“一源三岐”理论指导临床治疗卵巢功能性疾病的神经解剖基础
基金项目(Foundation): 国家重点研发计划资助项目(编号:2022YFC3500405); 国家自然科学基金面上项目(编号:82374586); 上海市卫生健康委员会中医药科研项目(编号:2022CX004)
邮箱(Email): mzhang30@sdutcm.edu.cn;
DOI: 10.16295/j.cnki.0257-358x.2024.12.003
发布时间: 2024-12-05
出版时间: 2024-12-05
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摘要:

根据任督冲脉循行特点,通过针灸三脉腧穴治疗胞宫疾病,这种取穴方法与“经脉-脏腑相关”理论吻合。“经脉-脏腑相关”理论揭示了经脉与脏腑之间的相互联系,在此理论指导下针灸治疗卵巢功能性疾病效果显著。本文通过梳理针灸起效的神经生物学机制研究,发现自主神经通过卵巢上神经及卵巢丛神经两条神经通路参与调节卵巢功能,而腹腔神经节-卵巢上神经-卵巢和肠系膜上神经节-卵巢丛神经-卵巢两条神经传导通路与任督冲脉起源及部分循行线路有一定的重合,这可能是任督冲脉治疗卵巢功能性疾病的神经生物学证据。进一步从任督冲三脉的循行与胞宫的联系出发,通过神经解剖和腧穴传导两个方面,分别对任脉、督脉、冲脉与卵巢上神经、卵巢丛神经两条神经通路之间存在的重合位点进行论述,以期为针灸治疗卵巢功能性疾病相关机制的深入研究提供思路。

Abstract:

According to the characteristics of the governor,conception and thoroughfare meridians circulation,different medical practitioners apply acupuncture and moxibustion at acupoints along the three meridians to treat uterine diseases. The “meridian-viscera correlation” theory reveals the interrelation between meridians and viscera. Under the guidance of this theory,acupuncture and moxibustion are effective in the treatment of ovarian functional diseases. This method of selecting acupoints is consistent with the theory of “meridian-viscera correlation”. Under the guidance of this acupoint selection principle,acupuncture and moxibustion has remarkable effect on ovarian functional diseases. This paper reviews the study on neurobiological mechanism of acupuncture and moxibustion effect,and finds that the autonomic nerve is involved in the regulation of ovarian function through two neural pathways,the superior ovarian nerve and the ovarian plexus nerve,while the nerve conduction of the two pathways,the celiac ganglion-superior ovarian nerve and the superior mesenteric ganglion-ovarian plexus nerve,has a certain overlap with the origin and part of the running routes of the governor,conception and thoroughfare meridians. This may be neurobio-logical evidence for the governor,conception and thoroughfare meridians treatment of ovarian functional diseases. Therefore,this paper further discusses the overlapping points between the governor,conception and thoroughfare meridians and the superior ovarian nerve and the ovarian plexus nerve respectively from the perspectives of neural anatomy and acupoints conduction,with a prospect of providing ideas for the in-depth study of the mechanism of acupuncture and moxibustion in the treatment of ovarian functional diseases.

参考文献

[1]李博灵,赵永烈,王丹萍,等.任、督、冲脉“一源三歧”“异名同体”探析[J].湖南中医药大学学报,2024,44(4):623-627.

[2]于秋敏,伍娟娟.中医药调控相关信号通路防治卵巢早衰的研究进展[J].辽宁中医药大学学报:2024,26(8):187-193.

[3]孙承颐,房繄恭.房繄恭“调经促孕十三针”治疗卵巢早衰经验[J].中国中医基础医学杂志,2020,26(9):1403-1405.

[4]侯林茹,赵文君,杨元祯,等.经脉-脏腑相关理论探析[J].针灸临床杂志,2024,40(3):1-6.

[5]高树中,陈永君.“经脉-脏腑相关”理论现代化诠释和发展思路[J].山东中医杂志,2024,43(8):781-787.

[6]李延平,刘勇前.浅谈“一源三岐”学说的形成和作用[J].中医药学报,2012,40(3):7-9.

[7]王哲,师伟.《景岳全书·妇人规》不孕证治导读[J].中医文献杂志,2008,26(5):28-30.

[8]吕晶武.《黄帝内经》奇经思想对后世妇科的影响[J].中国中医药现代远程教育,2019,17(23):24-26.

[9]赵铭宇,张金卉,翟含,等.《妇人大全良方》等十部中医妇科经典古籍的思维导图设计[J].中国中医药科技,2024,31(2):369-373.

[10]李晓杉,汪曦,马凤丽.张良英教授运用六味地黄丸加味治疗妇科病经验[J].云南中医中药杂志,2023,44(12):4-6.

[11]李晶晶,周英.从《景岳全书·妇人规》调经学术思想论岭南罗氏妇科的传承与发展[J].浙江中医杂志,2021,56(4):263-265.

[12]张玥,丛超,徐莲薇.浅析《傅青主女科》从补虚论治不孕症理论及其应用[J].光明中医,2023,38(2):228-232.

[13]王彦彦,黄旭春,王小云.叶天士调冲任治疗月经病特色初探[J].中华中医药杂志,2018,33(9):3828-3830.

[14]赵晓宇,赵红霞,胡妮娜,等.基于《医宗金鉴·妇科心法要诀》之妇科疾病六经辨治探析[J].江苏中医药,2022,54(11):66-68.

[15]梁瑞宁,范培,李佩双,等.冲任新说[J].中华中医药杂志,2019,34(1):69-71.

[16]孟竞璧,田嘉禾.十四经脉显像探秘[M].北京:中国科学技术出版社,1998:188-207.

[17]王燕平,张维波,李宏彦,等.《黄帝内经》任督二脉循行解析[J].中国针灸,2021,41(7):805-812.

[18]陈思,王佩娟.胞宫源流考[J].江西中医药大学学报,2023,35(6):1-4.

[19]马嘉敏,李芳源,朱璨,等.基于“一源三岐”探讨早发性卵巢功能不全的辨治思路[J].四川中医,2023,41(8):34-37.

[20]楼毅云,傅萍,董襄国.浅析《黄帝内经》不孕证治[J].浙江中医药大学学报,2017,41(1):52-54.

[21]王英姿.卵巢低反应中医研究进展[J].中华中医药杂志,2020,35(7):3542-3544.

[22]肖茜,纪亚忠.卵巢功能异常与妊娠结局相关性及其机制概述[J].海军军医大学学报,2024,45(4):383-390.

[23]武学清,孔蕊,田莉,等.卵巢低反应专家共识[J].生殖与避孕,2015,35(2):71-79.

[24]MAHESHWARI A,FOWLER P,BHATTACHARYA S.Assessment of ovarian reserve:should we perform tests of ovarian reserve routinely?[J].Hum Reprod,2006,21(11):2729-2735.

[25]郁琦,吴洁,陈蓉,等.早发性卵巢功能不全的激素补充治疗专家共识[C]//西南及四川省中医妇(产)科专科联盟成立大会论文集.成都:中华医学会妇产科学分会,2018:233-239.

[26]KALANTARIDOU S N,DAVIS S R,NELSON L M.Premature ovarian failure[J].Endocrinol Metab Clin N Am,1998,27(4):989-1006.

[27]杨思晨,王玲,章勤,等.中医药治疗卵巢功能减退性疾病研究文献可视化分析[J].中国中医药信息杂志,2023,30(4):34-40.

[28]莫莉菁,付伟平,朱琴,等.联合指标对多囊卵巢综合征患者发生卵巢高反应的预测价值[J].中国妇幼保健,2021,36(6):1324-1328.

[29]罗玺,李茜,程洁,等.针灸治疗卵巢早衰有效性的系统综述与Meta分析[J].中医杂志,2016,57(12):1027-1032.

[30]袁龙,刘鹏,李冰融,等.针灸相关疗法治疗卵巢早衰疗效的网状Meta分析[J].上海中医药杂志,2022,56(1):19-27.

[31]KANG H S,JEONG D,KIM D I,et al.The use of acupuncture for managing gynaecologic conditions:an overview of systematic reviews[J].Maturitas,2011,68(4):346-354.

[32]刘炜宏,陈超,王芳,等.关于针灸优势病种的思考[J].科技导报,2019,37(15):55-62.

[33]刘庭秀,任玥晗,仇兴华,等.针刺治疗胰岛素抵抗型多囊卵巢综合征疗效的Meta分析[J].世界中西医结合杂志,2023,18(10):1924-1933,1961.

[34]黄守强,徐海燕,熊俊,等.针灸治疗多囊卵巢综合征不孕症有效性的系统评价[J].中国循证医学杂志,2021,21(4):431-437.

[35]YANG H,XIAO Z Y,YIN Z H,et al.Efficacy and safety of acupuncture for polycystic ovary syndrome:an overview of systematic reviews[J].J Integr Med,2023,21(2):136-148.

[36]TIAN Z,ZHANG C,LIAO X,et al.Trends in acupuncture for infertility:a scoping review with bibliometric and visual analysis[J].Front Endocrinol,2024,15:1351281.

[37]金春兰,庞然,徐立鹏,等.针灸治疗多囊卵巢综合征临床选穴组方规律[J].中国针灸,2015,35(6):625-630.

[38]夏良君,夏有兵.近20年针灸治疗卵巢早衰的临床研究及作用机制进展[J].中国针灸,2018,38(5):565-570.

[39]马堃,韩梅,杨思红,等.排卵障碍性不孕症中西医结合诊疗指南[J].中医杂志,2024,65(9):976-984.

[40]郭建芳,邹如政,向小玲,等.基于“一源三岐”理论精准选穴针刺治疗早发性卵巢功能不全不孕的临床研究[J].湖北中医杂志,2023,45(2):31-34.

[41]单醒瑜,赖舒婷.督脉温针灸辅助治疗肾阳虚型PCOS所致不孕患者的效果[J].实用中西医结合临床,2022,22(10):105-107.

[42]杨丽鹍,王宁,陈新宇,等.针刺冲任脉腧穴对卵巢储备功能下降患者卵巢反应性的影响[J].中国中医药信息杂志,2023,30(11):167-172.

[43]周紫琼,杜雪莲,黄剑美,等.疏肝补肾结合调经促孕针刺治疗卵巢早衰临床观察[J].中华中医药学刊,2023,41(9):63-66.

[44]白杨,陈枝岚,弓爱东,等.调经促孕针法对卵巢储备功能减退患者IVF-ET妊娠结局的影响:队列研究[J].中国针灸,2024,44(6):653-658.

[45]孙颖超,于晓华,孙风峙,等.张晶教授运用奇经八脉理论针刺治疗卵巢早衰经验[J].按摩与康复医学,2022,13(22):77-80.

[46]LI E,WANG L,WANG D,et al.Control of lipolysis by a population of oxytocinergic sympathetic neurons[J].Nature,2024,625(7993):175-180.

[47]LOVELACE J W,MA J,YADAV S,et al.Vagal sensory neurons mediate the Bezold-Jarisch reflex and induce syncope[J].Nature,2023,623(7986):387-396.

[48]BALJET B,DRUKKER J.The extrinsic innervation of the abdominal organs in the female rat[J].Acta Anat,1979,104(3):243-267.

[49]SAKSOUK F A,JOHNSON S C.Recognition of the ovaries and ovarian origin of pelvic masses with CT[J].Radiographics,2004,24(Suppl 1):s133-s146.

[50]KAESTNER C L,SMITH E H,PEIRCE S G,et al.Immunohistochemical analysis of the mouse celiac ganglion:an integrative relay station of the peripheral nervous system[J].J Comp Neurol,2019,527(16):2742-2760.

[51]MCNEILL D L,BURDEN H W.Neuropeptide Y and somatostatin immunoreactive perikarya in preaortic ganglia projecting to the rat ovary[J].J Reprod Fertil,1986,78(2):727-732.

[52]GERENDAI I,TóTH I E,BOLDOGKOI Z,et al.Neuronal labeling in the rat brain and spinal cord from the ovary using viral transneuronal tracing technique[J].Neuroendocrinology,1998,68(4):244-256.

[53]LAWRENCE I E,BURDEN H W.The origin of the extrinsic adrenergic innervation to the rat ovary[J].Anat Rec,1980,196(1):51-59.

[54]PASTELíN C F,ROSAS N H,MORALES-LEDESMAL,et al.Anatomical organization and neural pathways of the ovarian plexus nerve in rats[J].J Ovarian Res,2017,10(1):18.

[55]DELSOUC M B,VALLCANERAS S,DANERI BECERRAC,et al.Superior mesenteric ganglion via ovarian plexus nerve involved in the cross-talk between noradrenaline and Gn RH in rat ovaries[J].Syst Biol Reprod Med,2023,69(2):87-100.

[56]AGUADO L I,OJEDA S R.Ovarian adrenergic nerves play a role in maintaining preovulatory steroid secretion[J].Endocrinology,1984,114(5):1944-1946.

[57]PASTELíN C F,ROSAS N H,MORALES-LEDESMAL,et al.Anatomical organization and neural pathways of the ovarian plexus nerve in rats[J].J Ovarian Res,2017,10(1):18.

[58]柳春梅,马玉侠,高树中.脐与胞宫相通的理论探讨[J].山东中医杂志,2013,32(8):525-526.

[59]PASTELIN C F,RIVERA-CASTRO M E,MIRTO-AGUILAR N,et al.Structural organization of the neuronal pathways of the superior ovarian nerve in the rat[J].J Ovarian Res,2023,16(1):25.

[60]李博灵,赵永烈,王丹萍,等.任、督、冲脉“一源三歧”“异名同体”探析[J].湖南中医药大学学报,2024,44(4):623-627.

[61]陈昕力,贺娟.《黄帝内经》“血脉”“经脉”概念辨析[J].中华中医药杂志,2022,37(12):6966-6969.

[62]周金山,晋志高,陶之理.关元一级感觉神经元在脊神经节的节段分布[J].上海针灸杂志,2001,20(3):40-41.

[63]刘巧玲,安晓飞,吴根诚,等.电针对“关元”穴区初级感觉传入神经元节段分布的影响[J].针刺研究,2006,31(1):50-53.

[64]孙莹璞,卜志勤.影响女性生育力的卵巢及输卵管相关疾病[J].中国实用妇科与产科杂志,2022,38(6):593-596.

[65]AGUADO L I.Role of the central and peripheral nervous system in the ovarian function[J].Microsc Res Tech,2002,59(6):462-473.

[66]孟卓,陶之理.大鼠脊髓灰质向孤束核的投射--HRP法研究[J].神经解剖学杂志,1986(1):141-146,179.

[67]赵婷婷,刘永康,周俊灵,等.基于静息态功能核磁共振成像研究针刺对早发性卵巢功能不全患者下丘脑功能连接的影响[J].针刺研究,2022,47(7):617-624.

[68]JIANG L,GENG H,LU M,et al.Acupuncture for poststroke hemiplegia focusing on cerebral bilateral connections:study protocol for a randomised controlled neuroimaging trial[J].BMJ Open,2020,10(4):e034548.

[69]李琳,金昌洙,谢书阳,等.经穴阻断后针刺关元穴对大鼠f MRI成像的研究[J].中华中医药学刊,2017,35(2):293-295.

[70]张凤,冯异,周瑞,等.正常和病理状态下“关元”穴的中枢神经束路示踪研究及电针的影响[J].针刺研究,2008,33(3):147-153.

[71]吴静怡,杨晨曦,包洁,等.基于“经脉-脏腑相关”理论探讨针刺治疗肠易激综合征的机制与临床应用[J].山东中医杂志,2024,43(8):788-794.

[72]WANG K,CAI B,SONG Y,et al.Somatosensory neuron types and their neural networks as revealed via single-cell transcriptomics[J].Trends Neurosci,2023,46(8):654-666.

基本信息:

DOI:10.16295/j.cnki.0257-358x.2024.12.003

中图分类号:R271.9

引用信息:

[1]薛松,颜靖岚,布雨,等.“一源三岐”理论指导临床治疗卵巢功能性疾病的神经解剖基础[J].山东中医杂志,2024,43(12):1326-1333.DOI:10.16295/j.cnki.0257-358x.2024.12.003.

基金信息:

国家重点研发计划资助项目(编号:2022YFC3500405); 国家自然科学基金面上项目(编号:82374586); 上海市卫生健康委员会中医药科研项目(编号:2022CX004)

发布时间:

2024-12-05

出版时间:

2024-12-05

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