目的:观察中药熏洗坐浴联合龙珠软膏外敷治疗慢性肛周湿疹的临床疗效。方法:将100例慢性肛周湿疹病例采用随机数字表法分成治疗组与对照组各50例,治疗组采用中药熏洗坐浴联合龙珠软膏外敷,对照组则采用派瑞松外敷治疗。以7 d为1个疗程,连续治疗2个疗程后对两组的肛周瘙痒程度、肛周皮肤渗液、肛周皮损面积和肛周皮损形态进行评分,比较两组的近期疗效;3个月左右门诊随访,比较两组的远期疗效。结果:①治疗2个疗程后两组肛周瘙痒程度、肛周皮肤渗液、肛周皮损面积和肛周皮损形态评分都比治疗前有所下降(P<0.05);且治疗组下降程度明显强于对照组(P<0.05);②治疗组近期和远期临床疗效均优于对照组(P<0.05)。结论:慢性肛周湿疹采用中药熏洗坐浴联合龙珠软膏外敷治疗,可以明显减轻肛周瘙痒症状,减轻肛周皮肤渗液,促进肛周皮损更快修复,近期和远期临床疗效较好。

Objective:To observe the clinical efficacy of fumigation and hip bath with Chinese medicinals combined with external application of Longzhu Ointment ( 龙珠软膏 ) in the treatment of chronic perianal eczema. Methods:One hundred patients with chronic perianal eczema were divided into treatment group and control group with a random number table,50 cases in each group. The treatment group was treated with fumigation and hip bath with Chinese medicinals combined with LongzhuOintment,while the control group was treated with pevisone externally. A treatment course lasted for 7 days.After two treatment courses,the degree of perianal pruritus,perianal skin exudation,perianal skin lesion area and perianal skin lesion morphology were scored,and the short-term efficacy in the two groups was compared;the long-term efficacy of the two groups was compared 3 months after the treatment. Results:(1)After two treatment courses,the degree of perianal pruritus,perianal skin exudation,perianal skin lesion area and perianal skin lesion morphology scores in the two groups were decreased compared with those before the treatment(P<0.05),and the decreases in the treatment group was more obvious than those in the control group(P<0.05).(2)The short-term and long-term clinical efficacy in the treatment group were better than those in the control group(P<0.05). Conclusions:Fumigation and hip bath with Chinese medicinals combined with external application of Longzhu Ointment for chronic perianal eczema could significantly relieve the symptoms of perianal pruritus,reduce perianal skin exudation,and promote the rapid recover of perianal skin lesions,with good short-term and long-term clinical efficacy.