慢性肾脏病（CKD）具有预后差和病程长的特点，且终末期肾病患者需要进行昂贵的肾脏替代治疗以维系生命，因此，CKD患者多长期承受沉重的心理和经济负担，并由此并发情志异常。余仁欢教授提出慢性肾脏病合并情志异常的主要病机为肾虚致郁，包括肾阴亏虚导致火无所涵而烦、肾阳不足导致志无所藏而恐、肾气亏虚导致气无所载而郁等。桂枝甘草龙骨牡蛎汤具有通阳敛阳、潜阳安神的功效，可用于治疗肾虚心神为阳邪所扰导致的烦躁。余教授治疗慢性肾脏病合并情志异常以该方为基础，根据不同证型加用调心安神、温阳健脾、疏肝解郁类方药，取得良好疗效。附验案1则。

Chronic kidney disease(CKD) is characterized by a poor prognosis and a long course. Moreover,patients with end-stage renal disease require expensive renal replacement therapy to sustain their lives.Therefore,most CKD patients endure heavy psycho-logical and economic burdens for a long time,and thus concurrently develop emotional disorders. Professor YU Renhuan proposed that the main pathogenesis of CKD complicated with emotional disorders is depression caused by kidney deficiency,including restlessness caused by deficiency of kidney yin resulting in fire without containment,fear caused by deficiency of kidney yang resulting in will without storage,and depression caused by deficiency of kidney qi resulting in qi without support,etc. Guizhi Gancao Longgu Muli Decoction（桂枝甘草龙骨牡蛎汤） has the efficacy of activating yang,restraining yang,and subduing yang to calm the mind. It can be used to treat restlessness caused by the disturbance of the mind and spirit by yang-pathogen due to kidney deficiency. Based on this formula,Professor YU treats CKD complicated with emotional disorders by adding prescriptions or drugs with efficacy of regulating the heart and calming the mind,warming yang and strengthening the spleen,and soothing the liver and relieving depression according to different syndrome types,which has achieved favorable therapeutic outcomes. One proved case is attached.