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目的 :运用Meta分析方法评价补阳还五汤治疗糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)的临床疗效。方法:检索中国知网、万方、维普等数据库中应用补阳还五汤治疗糖尿病周围神经病变的随机对照临床试验文献,筛选合格研究,应用Meta分析方法分析统计相关数据,获得相对可靠的临床疗效证据。结果:27篇文献符合纳入标准,Meta分析显示,补阳还五汤(包括补阳还五汤联合西药)治疗DPN的疗效与西药组比较差异有统计学意义[OR=5.95,95%CI=(4.76,7.45),Z=15.59,P<0.000 01];单纯补阳还五汤治疗DPN的疗效与西药组比较差异有统计学意义[OR=7.00,95%CI=(5.15,9.52),Z=12.40,P<0.000 01]。结论:补阳还五汤或补阳还五汤联合西药治疗DPN的疗效优于单纯西药组,但由于原始研究质量较低,结果可能存在局限性。
Abstract：Objective:To evaluate the effect of Buyang Huanwu decoction on treating diabetic peripheral neuropathy(DPN) by meta-analysis. Methods:Literature on the randomized controlled clinical trial of using Buyang Huanwu decoction treating DPN was retrieved from the CNKI,Wanfang Data,VIP and other related databases,and was screened to choose the qualified research. A meta-analysis was conducted to analyze the data.Results:There were 27 studies meeting with the inclusion criteria. Results of meta-analysis showed that Buyang Huanwu decoction or Buyang Huanwu decoction plus western medicine was different from western medicine in treating DPN,with statistical significance [OR=5.95,95% CI=(4.76,7.45),Z=15.59,P<0.000 01],and Buyang Huanwu decoction alone was different from western medicine alone in treating DPN,with statistical significance [OR=7.00,95% CI=(5.15,9.52),Z=12.40,P <0.000 01]. Conclusion:Buyang Huanwu decoction or Buyang huanwu decoction plus western medicine was superior to western medicine alone in treating DPN. The original study,however,was of poor quality,and there are certain defects in the results.
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基本信息:
DOI：10.16295/j.cnki.0257-358x.2016.02.008
中图分类号:R259
引用信息:
[1]史玲俊,郑承红.补阳还五汤治疗糖尿病周围神经病变的Meta分析[J].山东中医杂志,2016,35(02):108-111.DOI:10.16295/j.cnki.0257-358x.2016.02.008.
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