目的：探究参苓白术散加减联合腹针埋线在脾虚湿盛型单纯性肥胖患者中的应用效果。方法：选取105例脾虚湿盛型单纯性肥胖患者为研究对象，随机数字表法分为常规组、埋线组、联合组，每组35例。给予常规组生活指导，在此基础上，埋线组加用腹针埋线治疗，联合组加用腹针埋线+参苓白术散加减治疗。比较三组疗效、中医证候积分、肥胖体征[腰臀比、体质量指数（BMI）]、肠道菌群（双歧杆菌、拟杆菌、肠球菌DNA数）、血脂水平[总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）]及安全性。结果：联合组疗效分级优于常规组、埋线组（P<0.05），联合组、埋线组总有效率分别为94.29%、82.86%，均高于常规组（60.00%）(P<0.05)；治疗后，除常规组肠道菌群DNA数外，三组其他指标均较治疗前改善（P<0.05）；治疗后三组腰臀比、BMI，以及中医证候主症、次症、总积分比较，联合组<埋线组<常规组（P<0.05）；治疗后TC、TG及肠球菌DNA数比较，联合组<埋线组<常规组，HDL-C及拟杆菌、双歧杆菌DNA数比较，联合组>埋线组>常规组（P<0.05）；三组不良反应发生率比较，差异无统计学意义（P>0.05）。结论：参苓白术散加减联合腹针埋线治疗脾虚湿盛型单纯性肥胖患者效果可靠，可调节患者肠道菌群，改善脂质代谢与临床体征，且安全性高。

Objective:To explore the application effect of Modified Shenling Baizhu Powder(参苓白术散) combined with abdominal acupuncture catgut-embedding on patients with simple obesity of spleen deficiency and dampness excess type. Methods:A total of 105 patients with simple obesity of spleen deficiency and dampness excess type were selected as the research subjects and randomly divided into the conventional group,the catgut-embedding group and the combination group by using the random number table method,with 35 cases in each group. The conventional group was given life guidance. On this basis,the catgut-embedding group was treated with abdominal acupuncture catgut-embedding,and the combination group was treated with abdominal acupuncture catgut-embedding combined with modified Shenling Baizhu Powder. The curative effects,traditional Chinese medicine(TCM) syndrome scores,changes in obesity signs[waist-hip ratio,body mass index(BMI)],intestinal flora(DNA counts of bifidobacterium,Bacteroides,Enterococcus),blood lipid levels[total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),triglycerides(TG)] and safety of the three groups were compared. Results:The therapeutic effect classification of the combination group was superior to that of the conventional group and the acupuncture embedding group(P<0.05). The total effective rates of the combination group and the acupuncture embedding group were 94.29% and 82.86%,respectively,both of which were higher than that of the conventional group(60.00%)(P<0.05). After the treatment,except for the number of intestinal flora DNA in the conventional group,the other indicators of the three groups were all improved compared with those before the treatment(P<0.05). After treatment,the comparisons of waist-hip ratio,BMI,as well as the main symptoms,secondary symptoms and total score of TCM syndromes among the three groups showed that the combination group < the catgut-embedding group < the conventional group(P<0.05). After treatment,the comparison of TC,TG and enterococcus DNA numbers showed that the combination group < the catgut-embedding group < the conventional group,and the comparison of HDL-C and Bacteroides,Bifidobacterium DNA numbers showed that the combination group > the catgut-embedding group > the conventional group(all P<0.05). There was no statistically significant difference in the incidence of adverse reactions among the three groups(P>0.05). Conclusion:Modified Shenling Baizhu Powder combined with abdominal acupuncture catgut-embedding has a reliable effective therapeutic effect on patients with simple obesity of spleen deficiency and dampness excess type. It can regulate the intestinal flora of patients,improve lipid metabolism,alleviate clinical signs of patients,and has high safety.