目的:通过总结分析75例HIV感染者/艾滋病患者的临床资料,探讨其中医体质分布与T淋巴细胞亚群、HIV-RNA的关系。方法:收集未经高效抗逆转录病毒联合疗法治疗的28例HIV感染者、47例艾滋病患者的中医体质量表,判断其中医体质类型,同时检测其T淋巴细胞计数、HIV-RNA,分析中医体质与T淋巴细胞计数、HIV-RNA的关系。结果:艾滋病期平和质占5例(10.6%)、偏颇体质占42例(89.4%),无症状期平和质占8例(28.6%)、偏颇体质20例(71.4%);偏颇体质中艾滋病期最常见体质前四位依次是气虚质、湿热质、阴虚质、气郁质;无症状期最常见体质前四位依次是气虚质、湿热质、瘀血质、气郁质;艾滋病期与无症状期均以虚/虚实夹杂体质为主,与实性体质比较,差异具有统计学意义(P<0.05);CD4⁺水平较低的前四位体质依次是气虚质、阳虚质、气郁质、阴虚质,CD4⁺/CD8⁺较低的前四位依次是气虚质、湿热质、气郁质、阴虚质;气虚质患者的CD4⁺、CD8~+T淋巴细胞水平明显低于平和质(P<0.05);各体质间CD4⁺/CD8⁺差异无统计学意义(P> 0.05);虚性体质者CD8⁺水平最低,与平和质比较,差异有统计学意义(P<0.05);HIV-RNA较高的前四位体质依次是阴虚质、湿热质、阳虚质、气虚质,但各体质类型之间比较差异无统计学意义(P> 0.05)。结论:HIV/AIDS患者以气虚体质最多见,其T淋巴细胞计数较平和质低,各体质类型之间HIV-RNA水平差异无统计学意义。

Objective :To explore the correlation between traditional Chinse medicine(TCM) constitution types and T lymphocyte subsets and HIV-RNA by summarizing and analyzing the clinical data of 75 HIV infectors/AIDS patients. Methods:Using the TCM constitution scale to determine the TCM constitution types of 28 HIV infectors and 47 AIDS patients and also T lymphocyte subsets and HIV-RNA were detected,to analyze the correlation between TCM constitution types and T lymphocyte subsets and HIV-RNA. Results:In AIDS patients,5 patients(10.6%) were of mild constitution,42 patients(89.4%) were of biased constitution.In HIV infectors,8 patients(28.6%) were of mild constitution,and 20 patients(71.4%) were of biased constitution. Among biased constitution types,the top four in AIDS patients were qi deficiency,damp heat,yin deficiency,and qi stagnation,and the top four in HIV infectors were qi deficiency,damp heat,blood stasis,and qi stagnation. The constitution types of most HIV infectors and AIDS patients were deficient or deficient-excess complex,which was different from excess type,and the difference was statistically significant(P<0.05). In patients with the lowest CD4~+T lymphocyte the top four constitutions were qi deficiency,yang deficiency,qi stagnation,and yin deficiency;with the lowest CD4⁺/CD8⁺,the top four were qi deficiency,damp heat,qi stagnation,and yin deficiency;the CD4~+and CD8~+T lymphocytes in patients of qi deficiency constitution were significantly lower than that in patients with mild constitution(P<0.05);there was no significant difference in CD4⁺/CD8~+among all the TCM constitution types(P> 0.05). The level of CD8~+in patients of deficiency constitution was the lowest,and the difference was statistically significant compared with patients of mild constitution(P<0.05). In patients with the highest HIV-RNA,the top four constitutions were yin deficiency,damp heat,yang deficiency and qi deficiency,but there was no significant difference among all the TCM constitution types(P> 0.05). Conclusions:In HIV-positive individuals/AIDS patients,qi deficiency constitution is the most common,with lower level of T lymphocyte than that in mild constitution. However,there was no significant difference on HIV-RNA among all the TCM constitution types.