目的：探讨益气健脾方治疗2型糖尿病合并肥胖患者的临床疗效。方法：选取2型糖尿病合并肥胖患者85例，按照随机数字表法分为对照组41例与观察组44例。对照组给予饮食控制及运动治疗，并口服二甲双胍等降糖药物控制血糖；观察组在对照组基础上联合益气健脾方治疗。治疗3个月后比较两组患者治疗前后血糖指标、体质量指标、中医症状评分、临床疗效及不良反应发生情况。结果：治疗后，两组患者的空腹血糖、餐后2 h血糖、体质量及体质量指数（BMI）、中医症状评分均低于治疗前，差异有统计学意义（P<0.05或P<0.01）；且观察组低于对照组，差异有统计学意义（P<0.05或P<0.01）。两组治疗后糖化血红蛋白（HbA1c）均较治疗前降低（P<0.01），但组间比较差异无统计学意义（P>0.05）。观察组临床疗效优于对照组，差异有统计学意义（P<0.05）；观察组患者未发生不良反应事件，对照组发生低血糖1例，未出现其他不良反应，差异无统计学意义（P>0.05）。结论：益气健脾方治疗2型糖尿病合并肥胖安全有效，能够明显降低患者体质量，减轻患者临床症状，且未增加不良反应的发生。

Objective:To investigate the clinical effect of Yiqi Jianpi Formula（益气健脾方） on patients with type 2 diabetes mellitus combined with obesity. Methods:Total 85 patients with type 2 diabetes combined with obesity were selected. The patients were randomly divided into the control group(41 cases) and the observation group( 44 cases). The control group was given diet control and exercise therapy, and oral metformin and other hypoglycemic drugs to control blood glucose. On the basis of the treatment of the control group,the observation group was treated with Yiqi Jianpi Formula. After 3 months of treatment,the blood glucose index,body weight index,traditional Chinese medicine(TCM) symptom score,clinical efficacy and adverse reactions of the two groups were compared. Results:After treatment,the fasting blood glucose,2-hour postprandial blood glucose,body weight,body mass index(BMI) and TCM symptom scores of the two groups were lower than those before treatment,the differences were statistically significant(P<0.05 or P <0.01). The observation group was significantly lower than the control group,the differences were statistically significant(P <0.05 or P <0.01). The glycosylated hemoglobin(HbA1c) in two groups were lower than that before treatment(P<0.01). But the difference of the two groups was not statistically significant(P>0.05). The clinical effect of the observation group was better than that of the control group,the difference was statistically significant(P<0.05). There were no adverse events in the observation group,there was one case of hypoglycemia in the control group,and there was no other adverse reactions,the difference was not statistically significant(P>0.05). Conclusions:Yiqi Jianpi Formula is effective and safe in treating type 2 diabetes combined with obesity. It can significantly reduce the weight of patients,relieve the clinical symptoms of patients,and does not increase the incidence of adverse reactions.