目的:使用中医传承辅助系统(TCMISS)对中医内服方药治疗鼻咽癌放疗后口干用药、证型规律等进行分析。方法:检索并筛选1990年1月至2020年5月中国知网(CNKI)、维普资讯中文期刊服务平台及万方数据知识服务平台中关于中医药治疗鼻咽癌放疗后口干临床研究中的中药处方,利用TCMISS构建数据库后,运用关联规则及复杂系统的熵聚类等方法统计药物的使用频次,分析遣方规律并演算新方剂。结果:对筛选出的58首治疗鼻咽癌放疗后口干的中药方剂中136味中药进行分析,主要为滋阴药、清热药、益气药等,从中挖掘出10个核心中药组合并演算出5则新处方。结论:利用TCMISS对中医药治疗鼻咽癌放疗后口干用药规律及证型分析可知,中医药治疗本病常用滋阴清热法,其中麦冬、生地黄使用最多,使用药物多归肺、胃二经,多为苦、寒之品。常见的证型可归纳为肺燥津伤、阴虚内热、气阴两虚、痰瘀热结四型。演算出治疗核心中药组合及新方剂,对中医药治疗鼻咽癌放疗后口干有一定的参考意义。

Objective:To analyze the pattern types of radiotherapy-induced xerostomia in patients with nasopharyngeal carcinoma(NPC) and prescription rules by using traditional Chinese medicine inheritance support system(TCMISS). Methods:Literatures on treating radiotherapy-induced xerostomia in patients with NPC treated with Chinese medicinals from January 1990 to May 2020 were retrieved from CNKI,VIP and Wanfang Data,to establish a database through TCMISS. The frequency of Chinese medicinals was counted,the prescription rules were analyzed,and new formulas were invented by using the association rules and entropy clustering of complex system. Results:Totally,136 Chinese medicinals from 58 formulas for treating radiotherapy-induced xerostomia in patients with nasopharyngeal carcinoma were analyzed. They were mainly for nourishing yin,clearing heat and tonifying qi,in which 10 core combinations were mined and5 new formulas were determined. Conclusions :According to the pattern types of radiotherapy-induced xerostomia in patients with NPC and prescription rules by using TCMISS,medicinals for nourishing yin and clearing heat are commonly used in the treatment of this disease,in which Maidong(Radix Ophiopogonis) and Shengdihuang(Radix Rehmanniae Recens) are the most commonly used. They usually enter the lung and stomach meridians,of bitter flavor and cold property.Common syndromes usually involve the following four types:lung dryness and fluid deficiency,yin deficiency and internal heat,deficiency of qi and yin,intermingled phlegm,stasis and heat. The determined core combinations and new formulas could provides a reference for treating radiotherapy-induced xerostomia in patients with NPC with Chinese medicinals.