原发性骨髓纤维化（PMF）是一种恶性骨髓增殖性疾病，西医目前尚无特效疗法，中医药在改善症状、缓解病情、增效减毒方面独具优势。李达教授衷中参西，病证结合、多维辨析，认为瘀毒内蕴、脾肾两虚、正衰毒亢是PMF的基本病机，故临证以扶正祛邪为治则，提出健脾补肾、活血解毒、和解增效等治法，将内服与外敷有机结合，有效地改善了PMF患者贫血、巨脾及骨髓纤维化表现。附验案1则。

Primary myelofibrosis(PMF) is a malignant myeloproliferative disease. Western medicine has no specific treatment for it at present,but traditional Chinese medicine has unique advantages in relieving symptoms,alleviating the condition,enhancing the effect and reducing the toxicity. Professor LI Da combines diseases and syndromes with multidimensional analysis based on modern and traditional medicine theroies.He believes that the basic pathogenesis of PMF are the deficiency of spleen and kidney,blood stasis and toxin stagnation,deficiency of healthy qi and predominance of pathogenic factors. He proposes that invigorating spleen and tonifying kidney,promoting blood circulation and resolving toxin,reconciling and enhancing efficiency,and the combination of internal administration and external external application under the principle of strengthening healthy qi to eliminate pathogenic factors can effectively relieve the symptoms of anemia,giant spleen and myelofibrosis in PMF patients. One tested case is attached.