目的:观察梅花愈溃油治疗压疮的疗效,探索安全、简便、有效的压疮治疗方法。方法:选取压疮患者119例按随机数字表法分为两组,观察组60例,对照组59例。观察组予以梅花愈溃油联合"TIME"原则进行治疗,对照组予以湿润烧伤膏联合"TIME"原则进行治疗,对比观察两组创面的愈合率、肉芽生长情况、脓液渗出量、细菌阳性发生率、治疗效果和患者血清中白蛋白含量及D-二聚体水平。结果:治疗4周后两组压疮创面愈合率、肉芽生长情况评分均高于治疗前,观察组评分较对照组升高更明显(P<0.05);治疗4周后两组压疮创面脓液渗出量评分、细菌阳性发生率均低于治疗前,观察组指标较对照组降低更明显,差异具有统计学意义(P<0.05);治疗后两组压疮患者血清中白蛋白含量较治疗前升高,D-二聚体水平较治疗前降低,观察组变化较对照组更明显(P<0.05);治疗8周后,两组压疮创面治疗效果比较,差异具有统计学意义(P<0.05),且观察组优于对照组。结论:梅花愈溃油治疗压疮效果较好,可有效促进压疮创面的愈合。

Objective:To observe the efficacy of Meihua Yukui Oil（梅花愈溃油） in the treatment of pressure ulcers,and to explore a safe,simple and effective method for the treatment of pressure ulcers. Methods:Total119 patients with pressure ulcers were randomly divided into two groups,with 60 cases in the observation group and 59 cases in the control group. The observation group was treated with Meihua Yukui Oil combined with the “TIME” principle,and the control group was treated with Moist Exposed Burn Ointment combined with the “TIME” principle. The wound healing rate,granulation growth,pus exudation,bacterial positive rate,therapeutic effect,serum albumin content and D-dimer level of patients of two groups were compared and observed. Results:After 4 weeks of treatment,the wound healing rate and granulation growth score of the two groups were higher than those before treatment. The wound healing rate and granulation growth score of the observation group were significantly higher than those of the control group(P<0.05). After 4 weeks of treatment,the scores of pus exudation and the positive incidence of bacteria on the pressure ulcer wounds of the two groups were lower than those before treatment. The scores of pus exudation and the positive incidence of bacteria of the observation group were significantly lower than those of the control group,and the differences were statistically significant(P<0.05). After treatment,the serum albumin content of the two groups of pressure ulcer patients was higher than before treatment,and the D-dimer level was lower than before treatment. The changes in the observation group were more obvious than those in the control group(P<0.05). After 8 weeks of treatment,the pressure ulcer wound treatment effect of two groups was compared,the difference was statistically significant(P<0.05),and the observation group was better than the control group. Conclusion:Meihua Yukui Oil is effective in treating pressure ulcers and it can effectively promote the healing of pressure ulcers.