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目的：探讨六字诀对肺癌患者癌因性疲乏、肺功能及运动耐力的影响。方法：将62例肺癌患者随机分为对照组和观察组各31例，对照组进行常规药物治疗及健步走训练，观察组进行常规药物治疗及六字诀训练，在治疗前和治疗4周后对患者的Piper疲乏修订量表评分、第1秒用力呼吸量（FEV1）、用力肺活量（FVC）和6 min步行距离（6MWD）评分进行评估。结果：治疗前，两组患者的Piper疲乏修订量表评分、FEV1、FVC、6MWD评分比较，差异无统计学意义（P>0.05），治疗后，两组患者的Piper疲乏修订量表评分均显著降低（P<0.01），且观察组优于对照组（P<0.01）；两组患者的FEV1、FVC评分均显著增高（P<0.01），且观察组高于对照组（P<0.01）；两组6WMD评分均显著增高（P<0.01），且观察组高于对照组（P<0.01）。结论：六字诀训练可明显改善肺癌患者的癌因性疲乏症状，提高患者的肺功能、运动耐力，是一种有效的临床康复方案。
Abstract：Objective:To observe the effects of Liuzijue on cancer-related fatigue,lung function and exercise endurance in patients with lung cancer. Methods:A total of 62 patients with lung cancer were randomized into a control group and an experiment group,31 patients in each group. The control group was treated with walking training besides conventional medications,while the experiment group was treated with Liuzijue besides conventional medications. Before treatment and 4 weeks after treatment,the revised piper fatigue scale(PFS-R),forced expiratory volume in first second(FEV1),forced vital capacity(FVC),and six-minute walk test distance(6WMD)were used to evaluate patients. Results:Before treatment,there was no significant difference in PFS-R,FEV1,FVC and 6MWD scores between the two groups(P>0.05). After treatment,the PFS-R scores of both groups were significantly decreased(P<0.01),with more decrease in the experimental group(P<0.01). The FEV1 and FVC scores of the two groups were significantly increased(P<0.01),with more increase in the experimental group(P<0.01). The 6 WMD scores of the two groups were significantly increased(P<0.01),with more increase in the experimental group(P<0.01). Conclusion:The Liuzijue exercise can significantly improve the symptoms of cancer-related fatigue in patients with lung cancer,improve the lung function and exercise endurance of patients,and is an effective clinical rehabilitation protocol.
[1] BADE B C,DELA CRUZ C S. Lung cancer 2020:epidemiology,etiology,and prevention[J]. Clin Chest Med,2020,41(1):1-24.
[2] WU F Y,WANG L,ZHOU C C. Lung cancer in China:current and prospect[J]. Curr Opin Oncol,2021,33(1):40-46.
[3]朱杰，任晶晶，李晓芳，等.肺癌患者临床多功能障碍的发生情况分析[J].中国医刊，2022,57(1):53-57.
[4] BERGER A M,MOONEY K,ALVAREZ-PEREZ A,et al.Cancer-related fatigue,version 2.2015[J]. J Natl Compr Canc Netw,2015,13(8):1012-1039.
[5]李杰，王亚军.癌因性疲乏的中医药临床研究现状述评[J].中医药信息，2021,38(7):74-77.
[6]曹青青，艾冬梅，朱钱，等.“六字诀”及其应用[J].河南中医，2018,38(6):968-972.
[7]王丽.中国原发性肺癌诊疗规范（2015年版）[J].中华肿瘤杂志，2016,37(7):433-436.
[8] CELLA D,PETERMAN A,PASSIK S,et al. Progress toward guidelines for the management of fatigue[J]. Oncology,1998,12(11A):369-377.
[9] CAMPBELL K L,WINTERS-STONE K M,WISKEMANN J,et al. Exercise guidelines for cancer survivors:consensus statement from international multidisciplinary roundtable[J]. Med Sci Sports Exerc,2019,51(11):2375-2390.
[10] SCHMITZ K H,COURNEYA K S,MATTHEWS C,et al.American College of Sports Medicine roundtable on exercise guidelines for cancer survivors[J]. Med Sci Sports Exerc,2010,42(7):1409-1426.
[11] SO W K W,DODGSON J,TAI J W M. Fatigue and quality of life among Chinese patients with hematologic malignancy after bone marrow transplantation[J]. Cancer Nurs,2003,26(3):211-219.
[12] CRAPO R O,CASABURI R,COATES A L. ATS statement:guidelines for the six-minute walk test[J]. AM J Resp Crit Care,2002,166:111-117.
[13] PAULSEN O,KLEPSTAD P,ROSLAND J H,et al. Efficacy of methylprednisolone on pain,fatigue,and appetite loss in patients with advanced cancer using opioids:a randomized,placebo-controlled,double-blind trial[J].J Clin Oncol,2014,32(29):3221-3228.
[14] SOBIERAJ D M,WEEDA E R,NGUYEN E,et al. Association of inhaled corticosteroids and long-acting β-agonists as controller and quick relief therapy with exacerbations and symptom control in persistent asthma:a systematic review and meta-analysis[J]. JAMA,2018,319(14):1485-1496.
[15] YUN Y H,LEE K S,KIM Y W,et al. Web-based tailored education program for disease-free cancer survivors with cancer-related fatigue:a randomized controlled trial[J]. J Clin Oncol,2012,30(12):1296-1303.
[16] NEEFJES ECW,VAN DER VORST MJDL,BLAUWHOFFBUSKERMOLEN S,et al. Aiming for a better understanding and management of cancer-related fatigue[J].Oncologist,2013,18(10):1135-1143.
[17] JAGER A,SLEIJFER S,VAN DER RIJT C C. The pathogenesis of cancer related fatigue:could increased activity of pro-inflammatory cytokines be the common denominator?[J]. Eur J Cancer,2008,44(2):175-181.
[18]苏羚子，李柏.癌因性疲劳与下丘脑-垂体-肾上腺轴关系研究进展[J].中国康复理论与实践，2017,23(4):406-409.
[19] GERBER L H. Cancer-related fatigue:persistent,pervasive,and problematic[J]. Phys Med Rehabil Clin N Am,2017,28(1):65-88.
[20] SCHMIDT M E,SEMIK J,HABERMANN N,et al.Cancer-related fatigue shows a stable association with diurnal cortisol dysregulation in breast cancer patients[J]. Brain Behav Immun,2016,52:98-105.
[21]陈芳，胡玲春，叶敏华.肌肉训练联合有氧运动对肺癌化疗后癌因性疲乏患者下丘脑-垂体-肾上腺皮质轴的影响[J].中国现代医生，2022,60(13):98-101.
[22] COURNEYA K S,FRIEDENREICH C M,SELA R A,et al. The group psychotherapy and home-based physical exercise(group-hope)trial in cancer survivors:physical fitness and quality of life outcomes[J]. Psychooncology,2003,12(4):357-374.
[23]杜静，余红，徐倩，等.坐卧式“六字诀”对卒中后轻中度抑郁患者抑郁及自我效能的影响[J].护理学报，2021,28(13):70-73.
[24]刘太容，罗碧如，于正，等.穴位按摩联合六字诀呼吸操在慢性阻塞性肺疾病稳定期患者中的应用[J].护理学杂志，2018,33(5):41-44.
[25] XU S L,ZHANG D D,HE Q,et al. Efficacy of Liuzijue Qigong in patients with chronic obstructive pulmonary disease:a systematic review and meta-analysis[J]. Complement Ther Med,2022,65:102809.
[26]高亮，赵玉坤，王宇新.“六字诀”养生文化的起源、流变及其要义[J].体育与科学，2019,40(3):80-85.
[27]周国庆，姚新苗，李华，等.六字诀与腰椎核心稳定性训练的内在联系[J].康复学报，2016,26(4):47-51.
[28]李燕，苗立云，姜涵毅，等.术前肺通气功能对非小细胞肺癌术后生存的预测意义[J].中国呼吸与危重监护杂志，2013,12(2):167-172.
[29]李兰，倪娟，焦佳，等.五行音乐联合六字诀改善新型冠状病毒肺炎患者负性情绪的临床护理观察[J].湖南中医药大学学报，2021,41(5):765-769.
[30]袁天慧，朱迪，陈思阳，等.浅析心力衰竭的中医学康复运动疗法优势特色与潜在机制[J].中国中西医结合杂志，2023,43(12):1502-1509.
[31]吴利平，谭玉婷，方雪梅，等.六字诀呼吸操在社区老年患者COPD并开腹术后延续护理的应用[J].中医药导报，2017,23(5):111-114.
[32]屈玲玲，黄玲玲，卢雪萍.六字诀呼吸操在慢性阻塞性肺疾病患者延续性护理中的应用效果[J].中国乡村医药，2019,26(10):80-81.
[33] NEZU K,KUSHIBE K,TOJO T,et al. Recovery and limitation of exercise capacity after lung resection for lung cancer[J]. Chest,1998,113(6):1511-1516.
[34] WU W B,LIU X D,LIU J X,et al. Effectiveness of water-based Liuzijue exercise on respiratory muscle strength and peripheral skeletal muscle function in patients with COPD[J]. Int J Chron Obstruct Pulmon Dis,2018,13:1713-1726.
[35] MADOR M J,DENIZ O,AGGARWAL A,et al. Effect of respiratory muscle endurance training in patients with COPD undergoing pulmonary rehabilitation[J]. Chest,2005,128(3):1216-1224.
[36]李锐，卢伯春.健身气功对人体身心健康影响的研究进展[J].中国老年学杂志，2022,42(18):4638-4644.
基本信息:
DOI：10.16295/j.cnki.0257-358x.2024.07.012
中图分类号:R273
引用信息:
[1]苏航,毕鸿雁.六字诀干预对肺癌患者癌因性疲乏、肺功能及运动耐力的影响[J].山东中医杂志,2024,43(07):729-734+750.DOI:10.16295/j.cnki.0257-358x.2024.07.012.
基金信息:
山东省中医药科技发展计划重点基金项目（编号：2022090T）
2024-07-05
2024-07-05