目的：观察安胎止血散穴位贴敷辅助治疗肾虚型先兆流产的临床疗效。方法：选择肾虚型先兆流产患者100例，按随机数字表法分为安胎止血散穴位贴敷组和安慰剂穴位贴敷组各50例（安胎止血散穴位贴敷组脱落1例，安慰剂穴位贴敷组脱落3例）。安胎止血散穴位贴敷组采用黄体酮肌内注射及地屈孕酮片口服联合安胎止血散穴位贴敷神阙、双侧肾俞治疗，安慰剂穴位贴敷组采用黄体酮肌内注射及地屈孕酮片口服联合特制淀粉安慰剂穴位贴敷神阙、双侧肾俞治疗，两组均连续治疗2周。观察两组患者治疗前、治疗1周后、治疗2周后的血清孕酮、人绒毛膜促性腺素（HCG）、雌二醇水平及宫腔积血面积、孕囊大小、胚芽大小，评价两组患者的临床疗效和中医证候（腰酸、腹痛、阴道出血）疗效，比较两组患者治疗期间的不良反应情况。结果：治疗1周后和治疗2周后，两组患者的血清HCG、雌二醇水平均较治疗前升高（P<0.05），孕囊、胚芽均较治疗前增大（P<0.05）。治疗2周后，安胎止血散穴位贴敷组患者的宫腔积血面积较治疗前缩小（P<0.05），且小于安慰剂穴位贴敷组（P<0.05）。治疗后，安胎止血散穴位贴敷组临床总有效率和中医证候总有效率均高于安慰剂穴位贴敷组（P<0.05）。治疗期间，两组患者均未出现明显不良反应。结论：安胎止血散穴位贴敷神阙、双侧肾俞具有补益肾气、安胎止血的作用，该疗法能减少肾虚型先兆流产患者的宫腔积血，减轻患者腰酸、腹痛、阴道出血等症状，且对患者激素水平无明显影响，临床应用安全性更高。

Objective:To observe the clinical efficacy of acupoint application of Antai Zhixue Powder（安胎止血散） as an adjuvant therapy in the treatment of threatened abortion with kidney deficiency syndrome. Methods:A total of 100 patients with threatened abortion due to kidney deficiency were divided into an Antai Zhixue Powder acupoint application group and a placebo acupoint application group,with 50 patients in each group(1 case dropped out in the Antai Zhixue Powder acupoint application group,and 3 cases dropped out in the placebo acupoint application group). In the Antai Zhixue Powder acupoint application group,treatment was carried out using intramuscular injections of progesterone and oral administration of dydrogesterone tablets combined with Antai Zhixue powder acupoint application at Shenque point(CV8) and bilateral Shenshu points(BL23). In the placebo acupoint application group,treatment was conducted using intramuscular injections of progesterone and oral administration of dydrogesterone tablets combined with specially prepared starch placebo acupoint application at Shenque point and bilateral Shenshu points. Both groups were treated continuously for 2 weeks. The hematometra area,gestational sac size,embryo size,and the levels of serum progesterone,human chorionic gonadotropin(HCG),and estradiol of the patients in both groups were observed before treatment,1 week after treatment,and 2 weeks after treatment. The clinical curative efficacy and the curative efficacy of traditional Chinese medicine(TCM) syndromes(lumbago,abdominal pain,and vaginal bleeding) in both groups were evaluated. The adverse reactions of both groups during the treatment were compared. Results:At 1 week and 2 weeks post-treatment,the gestational sac and embryo of the patients in both groups were larger than those before treatment(P<0.05),and the levels of serum HCG and estradiol were higher than those before the treatment(P<0.05). After 2 weeks of treatment,the hematometra area of the patients in Antai Zhixue Powder acupoint application group was smaller than that before treatment(P<0.05),and was smaller than that in the placebo acupoint application group(P<0.05). After treatment,the total clinical effective rate and the total effective rate of TCM syndromes in the Antai Zhixue Powder acupoint application group were higher than those in the placebo acupoint application group(P<0.05). During the treatment period,no obvious adverse reactions were observed in either group. Conclusions:The acupoint application of Antai Zhixue Powder at the Shenque point and bilateral Shenshu points has the effect of tonifying kidney qi,preventing miscarriage,and stopping bleeding. This therapy can reduce hematometra in patients with threatened abortion due to kidney deficiency,alleviate symptoms such as lumbago,abdominal pain,and vaginal bleeding,and has no obvious influence on the hormone levels of patients. It is safer for clinical application.