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溃疡性结肠炎（UC）病理损伤的重要因素之一是免疫应答异常引起的炎症反应，炎症因子的过度表达是促进炎癌转化的重要因素，引起组织病理损伤，诱导上皮内瘤变，形成肿瘤。雷帕霉素靶蛋白（mTOR）作为调控细胞生长、自噬和免疫应答的核心通路，在UC及其癌变中发挥着双重作用：一方面通过抑制自噬，加剧肠道炎症；另一方面驱动癌细胞增殖。研究发现中医药可通过腺苷酸活化蛋白激酶（AMPK）-mTOR、蛋白激酶B(Akt)-mTOR等通路调控自噬、抑制炎症因子，且不良反应较少，为UC及炎癌转化提供了潜在治疗策略。具体而言，中药有效成分如黄连素、黄柏碱等，以及中药复方白头翁汤等，可通过激活AMPK通路负调控自噬，抑制mTOR磷酸化，促进细胞自噬，改善UC炎症反应；干姜提取物、人参根提取物等能抑制Akt-mTOR通路，减少炎症因子分泌，干预细胞凋亡。参考文献59篇。
Abstract：One of the important factors of pathological damage in ulcerative colitis(UC) is the inflammatory response caused by abnormal immune response. The overexpression of inflammatory cytokine is an important factor promoting the transformation of inflammation to cancer,causing histopathological damage,inducing intraepithelial neoplasia,and forming tumors. The mammalian target of rapamycin(mTOR),as the core pathway regulating cell growth,autophagy and immune response,plays a dual role in UC and its carcinogenesis:on the one hand,it aggravates intestinal inflammation by inhibiting autophagy;On the other hand,it drives the proliferation of cancer cells. Studies have found that traditional Chinese medicine can regulate autophagy and inhibit inflammatory cytokine through pathways such as amp-activated protein kinase(AMPK)-m TOR and Akt-mTOR,with relatively low adverse reactions,providing potential therapeutic strategies for treating UC and inflammation-cancer transformation. Specifically,the active ingredients of traditional Chinese medicine such as berberine and phellodenine,as well as the traditional Chinese medicine compound Baitouweng Decoction（白头翁汤）,can negatively regulate autophagy by activating the AMPK pathway,inhibit the phosphorylation of m TOR,promote autophagy in cells,and improve the inflammatory response of UC. Extracts of dried ginger,ginseng root,etc. can inhibit the Akt-m TOR pathway,reduce inflammatory cytokine secretion and intervene in cell apoptosis. There are 59 references.
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基本信息:
DOI：10.16295/j.cnki.0257-358x.2025.06.019
中图分类号:R259
引用信息:
[1]庞龙,孙大娟,迟莉丽.中医药调控mTOR通路干预溃疡性结肠炎及其癌变研究进展[J].山东中医杂志,2025,44(06):711-720.DOI:10.16295/j.cnki.0257-358x.2025.06.019.
基金信息:
国家自然科学基金项目（编号：82205057）
2025-06-05
2025-06-05