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纳米混悬技术为改善难溶性药物的溶解度,提高其生物利用度提供了一种新的途径,可望为中药难溶性成分的成药性提供新的解决方法。综述了中药难溶性成分纳米混悬剂的制备方法包括Top-down技术、Bottom-up技术以及联用技术,稳定剂选择包括表面活性剂和高分子聚合物,稳定性考察包括再分散性和晶型转变,给药途径包括口腔、经皮、鼻腔、肺部和注射给药,以及药物动力学和药理学研究等方面的研究进展。目前纳米混悬技术在中药难溶性成分中的研究和应用还处于初级阶段,研究的深度和广度有待于提高,本文可为进一步促进纳米混悬技术在中药难溶性成分中的应用提供参考。参考文献44篇。
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基本信息:
DOI:10.16295/j.cnki.0257-358x.2018.07.026
中图分类号:R283.6
引用信息:
[1]王绍花,牛余珍,张元元,等.纳米混悬技术提高中药难溶性成分溶解度的研究进展[J].山东中医杂志,2018,37(07):619-622.DOI:10.16295/j.cnki.0257-358x.2018.07.026.
基金信息:
山东省优秀中青年科学家科研奖励基金项目(编号:BS2014YY047)
2018-07-30
2018-07-30
2018-07-30