目的：探讨帕金森病（PD）患者中医证候与嗅觉障碍影响因素相关性。方法：2020年10月至2022年12月，随机纳入108例PD患者，采用SS-16测试、Hoehn-Yahr(H-Y)分期、蒙特利尔认知评估量表（MoCA）、新版世界运动障碍学会PD综合评价量表第三部分（MDS-UPDRSⅢ）等评估患者病情，以嗅觉测试结果分为嗅觉障碍组与嗅觉正常组。结果：PD患者嗅觉障碍发生率为65.7%，两组在年龄（P=0.006）、H-Y分期（P=0.012）、MoCA评分（P=0.016）、MDS-UPDRSⅢ评分（P=0.010）方面差异有统计学意义；二元Logistic回归分析提示嗅觉障碍与性别（OR=3.504,P=0.023）存在显著相关性。嗅觉障碍组与嗅觉正常组之间中医证候分布差异有统计学意义（P=0.017）。无序多分类Logistic回归分析提示，患者嗅觉障碍与否（OR=9.047,P=0.018）影响血瘀动风证与肝肾不足证两者诊断；MoCA评分（OR=1.146,P=0.046）影响患者气血两虚证与肝肾不足证两者诊断。结论：(1)嗅觉障碍组与嗅觉正常组中医证候存在差异；(2)嗅觉障碍有助于患者血瘀动风证与肝肾不足证两者的鉴别诊断。

Objective:To explore the correlation between traditional Chinese medicine(TCM) syndromes and dysosmia in patients with Parkinson's disease(PD). Methods:From October 2020 to December 2022 108patients with PD were included randomly. “Sniffin' Sticks” odor identification test(SS-16),Hoehn-Yahr(H-Y) staging,MoCA score,MDS-UPDRS Ⅲ were applied to evaluate patients. These patients were divided into normal olfactory group and dysosmia group according to the SS-16 test results. Results:The incidence of dysosmia in patients with PD was 65.7%. There were statistically significant differences in age(P=0.006),H-Y staging(P=0.012),Mo CA score(P=0.016) and MDS-UPDRS Ⅲ scores(P=0.010) between the two groups. Binary Logistic regression analysis indicated that there was a significant correlation between dysosmia and gender(OR=3.504,P=0.023). There was a significant difference in TCM syndrome distribution between the dysosmia group and the normal olfactory group(P=0.017). Disordered multiple logistic regression analysis suggested that the presence or absence of olfactory dysfunction in patients(OR=9.047,P=0.018) affects the diagnosis of blood stasis with wind stirring syndrome and liver and kidney deficiency syndrome;The Mo CA score(OR=1.146,P=0.046) affected the diagnosis of both qi and blood deficiency syndrome and liver and kidney deficiency syndrome in patients. Conclusions:There are differences in TCM syndromes between the dysosmia group and the olfactory normal group. The dysosmia affects the diagnosis of both blood stasis with wind stirring syndrome and liver and kidney deficiency syndrome in patients.