| 237 | 9 | 38 |
| 下载次数 | 被引频次 | 阅读次数 |
目的:观察苯妥英钠合用冰片对苯妥英钠血药浓度及脑组织分布的影响。方法:采用高效液相色谱法测定单用苯妥英钠及合用冰片在血液、脑组织中含量变化。结果:加入冰片前大鼠血液、脑组织中苯妥英钠的含量分别为9.65±0.19μg/m L,6.18±0.17μg/m L,加入冰片后,大鼠血液、脑组织中苯妥英钠含量有显著的提高。结论 :冰片可促进苯妥英钠吸收及透过血脑屏障,增强该药药效。
Abstract：Objective:To study the effect of phenytoin combined with borneol on content of phenytoin in blood and distribution of phenytoin in brain tissue. Methods:The content of phenytoin in blood and brain tissue when phenytoin was used alone and together with borneol was determined respectively by HPLC. Results:Before the the borneol was added, the contents of phenytoin in rats' blood and brain tissue were9.65 ±0.19 μg/m L and 6.18 ±0.17 μg/m L. when the borneol was added,the contents of phenytoin in rats' blood and brain tissue increased significantly. Conclusion:Borneol can promote the absorption of phenytoin and help phenytoin to penetrate the blood-brain barrier. It can enhance the effect of phenytoin.
[1]田文君,袁进,张荣,等.苯妥英钠临床应用[J].海峡药学,2007,19(7):74.
[2]陈新谦,金有豫,汤光.新编药物学[M].北京:人民卫生出版社,2007,1(16):219.
[3]苏煌财,林玉林,张宏.高效液相色谱法同时测定苯妥英钠和卡马西平的血药浓度[J].药品评价,2012,9(26):30-32.
[4]谭妙娟,官碧琼,唐慧德.高效液相色谱法测定苯妥英钠血药浓度结果及分析[J].今日药学,2013,23(7):412-423.
[5]刘红卫,杜文力,杜恩起,等.反相高效液相色谱法测定人血清中苯妥英钠浓度[J].河北医科大学学报,2011,22(6):340-341.
[6]王平,王晨,楼一层.冰片、川芎对复方舒郁健脑方剂透过血脑屏障的作用研究[J].湖北中医药大学学报,2011,13(5):21.
[7]陆茵,张大方.中药药理学[M].北京:人民卫生出版社,2012,6(1):244.
[8]吕旭潇,孙明江,孙凤志.冰片促进药物透过血脑屏障的研究进展[J].中国中药杂志,2012,37(7):878-880.
基本信息:
DOI：10.16295/j.cnki.0257-358x.2015.08.019
中图分类号:R285.5
引用信息:
[1]任赵燕,张卫国,杨莹,等.冰片对苯妥英钠血药及血脑浓度影响的实验研究[J].山东中医杂志,2015,34(08):605-606+617.DOI:10.16295/j.cnki.0257-358x.2015.08.019.
2015-08-24
2015-08-24
2015-08-24