周亚滨教授基于“木郁土虚”分期论治失眠，将中医基础理论与自身临床实践相结合，认为本病病因以情志失常最为多见，病机为“木郁土虚”致阴阳失衡而失眠。临床依据患者的不同表现分阶段论治：早期实中夹虚，肝郁脾虚，兼痰湿内停，治以疏肝解郁，辅以祛湿健脾；中期实中夹虚，肝火痰热，兼有气郁脾虚，治以清肝化痰，辅以解郁安中；后期虚中夹实，阴阳俱虚，虚热、肝郁、脾虚皆尚存，治以补益阴阳，辅以散郁补土。附验案1则。

ZHOU Yabin combines the basic theories of traditional Chinese medicine with his own clinical practice based on the staged treatment of insomnia caused by “ depression of the liver resulting in deficiency of the spleen” and believes that the most common cause of this disease is emotional disorder,and the pathogenesis is the insomnia which caused by the imbalance of yin and yang due to “depression of the liver resulting in deficiency of the spleen”. In clinical practice,he treats patients according to their different manifestations in different stages:In the early stage,there is a combination of excess and deficiency,with liver depression and spleen deficiency,and internal retention of phlegm and dampness. The treatment focuses on soothing the liver and relieving depres-sion,supplemented by eliminating dampness and strengthening the spleen. In the middle stage,there is a mixture of excess and deficiency,liver fire and phlegm-heat,accompanied by qi stagnation and spleen deficiency. The treatment focuses on clearing the liver and resolving phlegm,supplemented by relieving depression and stabilizing the middle. In the late stage,there is a mixture of deficiency and excess,with deficiency of both yin and yang,and residual heat,liver depression,and weak spleen persist. The treatment should focus on tonifying yin and yang,supplemented by dispelling depression and nourishing the spleen. One test case is attached.