高脂血症是指由各种原因引起的血浆中总胆固醇(TC)、三酰甘油(TG)和(或)低密度脂蛋白胆固醇(LDL-C)过高和(或)高密度脂蛋白胆固醇(HDL-C)过低的一种代谢性疾病,又称脂代谢异常或紊乱,是动脉粥样硬化、脂肪肝、糖尿病等多种疾病的危险因素。中医古代文献并没有对高脂血症的记载,现代医家大多描述其为痰湿、湿浊、瘀血等。茵陈蒿汤清疏、清利、清泄三法合用,为治疗肝胆湿热黄疸之主方,主要用于治疗病毒性肝炎、胆石症、胆囊炎等疾病,现代研究发现用其治疗高脂血症也颇有成效。从高脂血症与茵陈蒿汤证病因病机的比较、茵陈蒿汤治疗高脂血症的中医分析以及其处方组成药味茵陈、栀子、大黄的现代药理研究三个方面,探讨了茵陈蒿汤有效治疗高脂血症的机制。

Hyperlipidemia is a metabolic disease,also called abnormal lipid metabolism or lipid metabolism disorder,manifesting as high total cholesterol,high triglyceride and(or) high low density lipoprotein cholesterol(LDL-C),and(or) low high density lipoprotein cholesterol(HDL-C). Hyperlipidemia is a risk factor for various diseases such as atherosclerosis,fatty liver,and diabetes. In the ancient literature of traditional Chinese medicine(TCM),there is no record of hyperlipidemia. The contemporary physicians usually regard it as phlegm dampness,damp turbidity and blood stasis. Yinchenhao Decoction integrating three methods of soothing,draining and discharging,is a major TCM formula for treating jaundice with damp-heat in the liver and gallbladder,and now is mainly applied for viral hepatitis,cholelith disease and cholecystitis. Recent researches have shown that Yinchenhao Decoction is effective in the treatment of hyperlipidemia. In this article,disease causes of hyperlipidemia and Yinchenhao Decoction disease are compared,hyperlipidemia treated with Yinchenhao decoction is analyzed with TCM theory,and the major herbs in the formula,yinchen(Artemisiae Scopariae Herba),zhizi(Gardeniae Fructus),dahuang(Rhei Radix et Rhizoma) are studied by modern pharmacology. The mechanism for Yinchenhao decoction treating hyperlipidemia is studied.